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Khan, M.S.Y.
- Synthesis of Some New Prodrugs of Sulphonamides and Studies on Their Antimicrobial and Anti-Inflammatory Action
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, 110 062, IN
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, 110 062, IN
Source
Scientia Pharmaceutica, Vol 70, No 3 (2002), Pagination: 277-286Abstract
Various amide-based prodrugs of sulphonamides have been synthesised by condensing appropriate sulphonamide moiety with different β-aroyl propionic acids. All the compounds have been evaluated for their antimicrobial and anti-inflammatory activities. Their structures were established on the basis of elemental analysis, 1H NMR and Mass spectral data. Some of these compounds were found to have significant activity.Keywords
Sulphonamides, Prodrugs, Amides, Anti-Inflammatory, Antimicrobial
References
- Northey E. H. (1948), The sulfonamides and allied compounds, American Chemical Society Monograph Sereis, Reinhold, NewYork.
- Sabin A. B., Warren J. (1941), J. Bacteriol. 41 (M 50): 80.
- Forster W. G., McGlbeny'J. R. (1944), Am. J. Ophthalmol. 27C: 1107.
- Schwartz W. B. (1949), New Engl. J. Med. 240.
- Anand N. (1979), Wolf M. E. (ed.), Burger's Medicinal Chemistry, ed.4, Wiley-Interscience-NewYork, p. 34.
- Husain A. (2000), Ph.D. Thesis, Jamia Hamdard (Hamdard University), New Delhi, India.
- Testa B.. Jenner P. (1976). Drug Metabolism, Chemical and Biochemical aspect, Marcel Dekker Inc-New York, p. 138.
- Kohler C., Tolman E., Wooding W. Ellenbogen L. (1980), Arzneim-Forsch 30(4A): 702.
- Sloboda A. E., Tolman E. L., Osterberg A. C., Panagides J. (1980), Arzneim-Forsch 30(4A) 716.
- Winter C. A., Risley E. A. Nuss G. N. (1962), Proc. Soc. Exp. Biol. 111 : 544.
- Newbould B. B. (1963), Brit. J. Pharmacol. 21 : 157.
- Wilhemi G.. Menass-Gdynia R. (1972), Pharmacology 8: 321.
- Cruickshank R., Dugid J. P., Marmion D. P. Swain R. H. A. (1975), Medical Microbiology Vol. 2. Churchill-Livingstone - Edinburge - London, p. 2.
- Synthesis and Antibacterial Evaluation of New Flavonoid Derivatives from 4,6-Diacetyl Resorcinol
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, IN
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, IN
Source
Scientia Pharmaceutica, Vol 70, No 3 (2002), Pagination: 287-294Abstract
In order to check the antibacterial potential of bischalcones derived from 4,6-diacetyl resorcinol, a number of chalcone derivatives were synthesized by condensation with appropriate aromatic aldehydes. Out of these compounds 3b-i, 4a and 4b showed a good antibacterial activity. Methylation of the two chelated hydroxyls reduced the activity. However, oxidative cyclization of 3a and 3b resulted in compounds 4a and 4b which were found to be considerably active. The alternative method of synthesis of 4a and 4b via Baker-Venkatararnan rearrangement did not succeed.Keywords
Flavones, Bischalcones, Resorcinol, AntibacterialReferences
- Szent-Gyorgyi A. Z. (1938), Physio. Chem. 225: 126.
- Marrian D. H., Russel P. B., Todd A. R. (1947), J. Chem. Soc. 1419.
- Carpenedo F., Ferrari M., Santi S. (1967), Acta Isotop. 7: 271.
- De-Eds F. (1968), Comprehensive Biochemistry 20: 127.
- Gabor M., Sallai J., Szell T., Sipas G. Y. (1967), Acta Microbial. Acad. Sci. 14: 45.
- Munden J. E., Butterworth D., Hanscowb G., Verrall M. S. (1970), Appl. Microbiol. 19: 718.
- Lespagnol A., Lespagnol C., Lesieur D., Ca Zin M., Beerens H., Romond C. (1972), Chim. Ther. 7: 365.
- Marchalli R., Vining L. C. (1973), Chem. Commun. 555.
- Komatsu M., Tomimori T., Hatakeyarno K., Katsou M. (1973), Japanese Patent, 931 : 7311; Chem. Abs. (1973), 79: 63637.
- Wurm G., Lachmann C. (1974), Arch. Pharm. 307: 695.
- Genovese D., Conti C., Tomao P., Desideri N., Stein M., Catone S., Fiore L. (1995), Antiviral Research 27: 123.
- Sonare S. S., Vidhale N. N. (1994), Asian J. Chem. 6: 718.
- Bany A. L. (1976), The antimicrobial susceptibility test: Principle and Practice, Illus Lea and Febiger-Philadelphia, p. 180.